Extracellular matrix composition of Collagens I, Ill, IV, V, VII and other structural proteins provides a natural scaffold to facilitate cellular adhesion while assisting cellular migration and proliferation.
Interleukin-1 receptor antagonists(IL-1RA) and Tissue Inhibitor of Metalloproteinase (TIMP) 1,2,3,4 proteins present in amniotic tissues have been shown to decrease inflammation and pain.
Growth factors found in amniotic tissue such as PDGF, VEGF, EGF, FGF and TGF-B promote cellular proliferation and new collagen formation and minimize scar tissue formation.
Amniotic tissues have been described as immune-privileged because they rarely evoke an immune response in the human body.
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